Effect of C60 Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy

Журнал/Серія :
Life
Том :
12
ISSN :
2075-1729
Початкова сторінка :
1
Кінцева сторінка :
13
Дата випуску :
2022
Автор(и) :
Taras Shevchenko National University of Kyiv
Prylutska Svitlana
Department of Physiology, Plant Biochemistry and Bioenergetics, Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine
Taras Shevchenko National University of Kyiv
Nurishchenko Natalia Y.
Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv
Abramchuk Olga
Department of Human and Animal Physiology, Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University
Motuziuk Olexandr
Department of Human and Animal Physiology, Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University
Taras Shevchenko National University of Kyiv
Scharff Peter
Institute of Chemistry and Biotechnology, Technical University of Ilmenau
Ritter Uwe
Institute of Chemistry and Biotechnology, Technical University of Ilmenau
Анотація :
Biomechanical and biochemical changes in the muscle soleus of rats during imitation of hind limbs unuse were studied in the model of the Achilles tendon rupture (Achillotenotomy). Oral administration of water-soluble C60 fullerene at a dose of 1 mg/kg was used as a therapeutic agent throughout the experiment. Changes in the force of contraction and the integrated power of the muscle, the time to reach the maximum force response, the mechanics of fatigue processes development, in particular, the transition from dentate to smooth tetanus, as well as the levels of pro- and antioxidant balance in the blood of rats on days 15, 30 and 45 after injury were described. The obtained results indicate a promising prospect for C60 fullerene use as a powerful antioxidant for reducing and correcting pathological conditions of the muscular system arising from skeletal muscle atrophy.
Бібліографічний опис :
Nozdrenko, D.; Prylutska, S.; Bogutska, K.; Nurishchenko, N.Y.; Abramchuk, O.; Motuziuk, O.; Prylutskyy, Y.; Scharff, P.; Ritter, U. Effect of C60 Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy. Life 2022, 12, 332. https://doi.org/ 10.3390/life12030332
Ключові слова :

muscle soleus of rat

achillotenotomy

atrophy

C60 fullerene

biomechanical and bio...

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