Analysis of Biomechanical and Biochemical Markers of Rat Muscle Soleus Fatigue Processes Development during Long-Term Use of C60 Fullerene and N-Acetylcysteine
Тип публікації :
Стаття
Дата випуску :
2022
Автор(и) :
Taras Shevchenko National University of Kyiv
Prylutska Svitlana
Department of Physiology, Plant Biochemistry and Bioenergetics, Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine
Taras Shevchenko National University of Kyiv, Taras Shevchenko National University of Kyiv:, Taras Shevchenko University of Kyiv
Cherepanov Vsevolod
Department of Physical Electronics, Institute of Physics, NAS of Ukraine
Senenko Anton
Department of Physical Electronics, Institute of Physics, NAS of Ukraine
Vygovska Oksana
Department of Pediatric Infectious Diseases, Bogomolets National Medical University of Kyiv
Khrapatyi Sergii
Department of Computational Mathematics and Computer Modeling, Interregional Academy of Personnel Management
Ritter Uwe
Institute of Chemistry and Biotechnology, Technical University of Ilmenau
Taras Shevchenko National University of Kyiv
Piosik Jacek
Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk
Мова основного тексту :
Англійська
eKNUTSHIR URL :
DOI :
Журнал :
Nanomaterials
Том :
12
ISSN :
2079-4991
Цитування :
[APA 7] Nozdrenko, D., Prylutska, S., Bogutska, K., Cherepanov, V., Senenko, A., Vygovska, O., Khrapatyi, S., Ritter, U., Prylutskyy, Y., & Piosik, J. (2022). Analysis of Biomechanical and Biochemical Markers of Rat Muscle Soleus Fatigue Processes Development during Long-Term Use of C60 Fullerene and N-Acetylcysteine. Nanomaterials, 12. https://doi.org/10.3390/nano12091552
[ДСТУ] Analysis of Biomechanical and Biochemical Markers of Rat Muscle Soleus Fatigue Processes Development during Long-Term Use of C60 Fullerene and N-Acetylcysteine / D. Nozdrenko et al. Nanomaterials. 2022. Vol. 12. DOI: 10.3390/nano12091552 (date of access: 18.07.2026).
The development of an effective therapy aimed at restoring muscle dysfunctions in clinical and sports medicine, as well as optimizing working activity in general remains an urgent task today. Modern nanobiotechnologies are able to solve many clinical and social health problems, in particular, they offer new therapeutic approaches using biocompatible and bioavailable nanostructures with specific bioactivity. Therefore, the nanosized carbon molecule, C60 fullerene, as a powerful antioxidant, is very attractive. In this study, a comparative analysis of the dynamic of muscle soleus fatigue processes in rats was conducted using 50 Hz stimulation for 5 s with three consistent pools after intraperitoneal administration of the following antioxidants: C60 fullerene (a daily dose of 1 mg/kg one hour prior to the start of the experiment) and N-acetylcysteine (NAC; a daily dose of 150 mg/kg one hour prior to the start of the experiment) during five days. Changes in the integrated power of muscle contraction, levels of the maximum and minimum contraction force generation, time of reduction of the contraction force by 50% of its maximum value, achievement of the maximum force response, and delay of the beginning of a single contraction force response were analyzed as biomechanical markers of fatigue processes. Levels of creatinine, creatine phosphokinase, lactate, and lactate dehydrogenase, as well as pro- and antioxidant balance (thiobarbituric acid reactive substances, hydrogen peroxide, reduced glutathione, and catalase activity) in the blood of rats were analyzed as biochemical markers of fatigue processes. The obtained data indicate that applied therapeutic drugs have the most significant effects on the 2nd and especially the 3rd stimulation pools. Thus, the application of C60 fullerene has a (50–80)% stronger effect on the resumption of muscle biomechanics after the beginning of fatigue than NAC on the first day of the experiment. There is a clear trend toward a positive change in all studied biochemical parameters by about (12–15)% after therapeutic administration of NAC and by (20–25)% after using C60 fullerene throughout the experiment. These findings demonstrate the promise of using C60 fullerenes as potential therapeutic nanoagents that can reduce or adjust the pathological conditions of the muscular system that occur during fatigue processes in skeletal muscles.
Галузі знань та спеціальності :
09 Біологія::091 Біологія та біохімія
Галузі науки і техніки (FOS) :
Біологічні науки
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