The redeeming features of reaction of the 8-formyl-7-hydroxychromones with malononitrile

Lozinski, O., Shokol, T., Shishkin, O., Medvediev, V., Khilya, V. (2014). The redeeming features of reaction of the 8-formyl-7-hydroxychromones with malononitrile. French-Ukrainian Journal of Chemistry, 2(1), 10–15. https://doi.org/10.17721/fujcV2I1P10-15

A range of 4H,8H-pyrano[2,3-f]chromen-4,8-diones have been prepared using Knoevenagel reaction of the 8-formyl-7-hydroxychromones with malononitrile. The 4H,8H-pyrano[2,3-f]chromen-4,8-dione derivative was also obtained through the acid hydrolysis of the 8-imino-4H,8H-pyrano[2,3-f]chromen-4-one. 8-Formyl-7-hydroxychromone 1 was found to add two molecules of malononitrile through Michael addition resulting in formation of the 2-[8-amino-3-(4-chlorophenyl)-9-cyano-2-methyl-4-oxo-4H,10H-pyrano[2,3-f]chromen-10-yl]malononitrile. Supplementary information (CIF file)