Functionalized Derivatives of 2-azaspiro[3.3]heptane-1-carboxylic Acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic Acid for Drug Design

Kirichok, A., Yegorova, T. (2023). Functionalized Derivatives of 2-azaspiro[3.3]heptane-1-carboxylic Acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic Acid for Drug Design. French-Ukrainian Journal of Chemistry, 11(2), 31–38. https://doi.org/10.17721/fujcV11I2P31-38

2-azaspiro[3.3]heptane-1-carboxylic acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic acid, which had been reported as bioisoster of well-known pipecolic acid, were subjected to chemical transformations, resulting in a number of functionalized derivatives. The obtained molecules contained diversified functional groups, allowing their incorporation in bioactive compounds in versatile modes. Described synthetic approaches afforded multigram-scaled synthesis of the desired compounds with good yields, thus being applicable in drug design