Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and -dynamic data

[APA 7] Комаров, І. В., Ganna, T., Halyna, K., Natalia, D., Petro, I. Y., Штанова, Л. Я., Stanislav, P. V., Гарманчук, Л. В., Nataliia, K., Oleksandr, G., Довбинчук, Т. В., Petro, B., Oleg, B., Tim, S., Anne, S. U., & Sergii, A. (2022). Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and -dynamic data. Journal of Photochemistry and Photobiology B: Biology, 233. https://doi.org/10.1016/j.jphotobiol.2022.112479

[ДСТУ] Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and -dynamic data / І. В. Комаров et al. Journal of Photochemistry and Photobiology B: Biology. 2022. Vol. 233. DOI: 10.1016/j.jphotobiol.2022.112479 (date of access: 18.07.2026).

An in vivo study of a photoswitchable cytotoxic peptide LMB040 has been undertaken on a chemically induced hepatocellular carcinoma model in immunocompetent rats. We analysed the pharmacokinetic profile of the less toxic photoform (“ring-closed” dithienylethene) of the compound in tumors, plasma, and healthy liver. Accordingly, the peptide can reach a tumor concentration sufficiently high to exert a cytotoxic effect upon photoconversion into the more active (“ring-open”) photoform. Tissue morphology, histology, redox state of the liver, and hepatic biochemical parameters in blood serum were analysed upon treatment with (i) the less active photoform, (ii) the in vivo light-activated alternative photoform, and (iii) compared with a reference chemotherapeutic 5-fluorouracil. We found that application of the less toxic form followed by a delayed in vivo photoconversion into the more toxic ring-open form of LMB040 led to a higher overall survival of the animals, and signs of enhanced immune response were observed compared to the untreated animals.

Ключові слова :

Anticancer peptides Hepatocellular carcinoma Molecular photoswitches Pharmacokinetics Pharmacodynamics Photopharmacology

Галузі знань та спеціальності :

09 Біологія

Галузі науки і техніки (FOS) :

Природничі науки

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Adobe PDF

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3.09 MB

Контрольна сума :

(MD5):01eb77684ec7fdb5c4838623ac1bb79f

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