Microbiota substances modulate dendritic cells activity: A critical view
Тип публікації :
Стаття
Дата випуску :
2024
Автор(и) :
Natalia Khranovska
Danylo Ostapchenko
Iryna Tymoshenko
Nazarii Kobyliak
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Том :
10
Випуск :
5
ISSN :
2405-8440
Цитування :
[APA 7] Швець, Ю. В., Natalia, K., Сенчило, Н. В., Danylo, O., Iryna, T., Онисенко, С. В., Nazarii, K., & Фалалєєва, Т. М. (2024). Microbiota substances modulate dendritic cells activity: A critical view. Heliyon, 10(5). https://doi.org/10.1016/j.heliyon.2024.e27125
[ДСТУ] Microbiota substances modulate dendritic cells activity: A critical view / Ю. В. Швець et al. Heliyon. 2024. Vol. 10, no. 5. DOI: 10.1016/j.heliyon.2024.e27125 (date of access: 25.07.2026).
Contemporary research in the field of microbiota shows that commensal bacteria influence physiological activity of different organs and systems of a human organism, such as brain, lungs, immune and metabolic systems. This influence is realized by various processes. One of them is trough modulation of immune mechanisms. Interactions between microbiota and the human immune system are known to be complex and ambiguous. Dendritic cells (DCs) are unique cells,
which initiate the development and polarization of adaptive immune response. These cells also interconnect native and specific immune reactivity. A large set of biochemical signals from microbiota in the form of different microbiota associated molecular patterns (MAMPs) and bacterial metabolites that act locally and distantly in the human organism. As a result, commensal bacteria influence the maturity and activity of dendritic cells and affect the overall immune reactivity of the human organism. It then determines the response to pathogenic microorganisms, inflammation, associated with different pathological conditions and even affects the effectiveness of vaccination
which initiate the development and polarization of adaptive immune response. These cells also interconnect native and specific immune reactivity. A large set of biochemical signals from microbiota in the form of different microbiota associated molecular patterns (MAMPs) and bacterial metabolites that act locally and distantly in the human organism. As a result, commensal bacteria influence the maturity and activity of dendritic cells and affect the overall immune reactivity of the human organism. It then determines the response to pathogenic microorganisms, inflammation, associated with different pathological conditions and even affects the effectiveness of vaccination
Галузі знань та спеціальності :
09 Біологія
Галузі науки і техніки (FOS) :
Природничі науки
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Формат :
Adobe PDF
Розмір :
3.32 MB
Контрольна сума :
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