Effect of C60 Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy

Nozdrenko, Dmytro; Prylutska Svitlana; Bogutska, Kateryna; Nurishchenko Natalia Y.; Abramchuk Olga; Motuziuk Olexandr; Prylutskyy, Yuriy; Scharff Peter; Ritter Uwe

doi:10.3390/life12030332

Effect of C60 Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy

Тип публікації :

Стаття

Дата випуску :

2022

Автор(и) :

Nozdrenko, Dmytro

Taras Shevchenko National University of Kyiv

Prylutska Svitlana

Department of Physiology, Plant Biochemistry and Bioenergetics, Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine

Bogutska, Kateryna

Taras Shevchenko National University of Kyiv

Nurishchenko Natalia Y.

Department of Biophysics and Medical Informatics, ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv

Abramchuk Olga

Department of Human and Animal Physiology, Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University

Motuziuk Olexandr

Department of Human and Animal Physiology, Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University

Prylutskyy, Yuriy

Taras Shevchenko National University of Kyiv

Scharff Peter

Institute of Chemistry and Biotechnology, Technical University of Ilmenau

Ritter Uwe

Institute of Chemistry and Biotechnology, Technical University of Ilmenau

Мова основного тексту :

Англійська

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/5888

DOI :

10.3390/life12030332

Журнал :

Life

Том :

12

ISSN :

2075-1729

Початкова сторінка :

1

Кінцева сторінка :

13

Цитування :

[APA 7] Nozdrenko, D., Prylutska, S., Bogutska, K., Nurishchenko, N. Y., Abramchuk, O., Motuziuk, O., Prylutskyy, Y., Scharff, P., & Ritter, U. (2022). Effect of C60 Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy. Life, 12, 1–13. https://doi.org/10.3390/life12030332

[ДСТУ] Effect of C60 Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy / D. Nozdrenko et al. Life. 2022. Vol. 12. P. 1—13. DOI: 10.3390/life12030332 (date of access: 25.07.2026).

Biomechanical and biochemical changes in the muscle soleus of rats during imitation of hind limbs unuse were studied in the model of the Achilles tendon rupture (Achillotenotomy). Oral administration of water-soluble C60 fullerene at a dose of 1 mg/kg was used as a therapeutic agent throughout the experiment. Changes in the force of contraction and the integrated power of the muscle, the time to reach the maximum force response, the mechanics of fatigue processes development, in particular, the transition from dentate to smooth tetanus, as well as the levels of pro- and antioxidant balance in the blood of rats on days 15, 30 and 45 after injury were described. The obtained results indicate a promising prospect for C60 fullerene use as a powerful antioxidant for reducing and correcting pathological conditions of the muscular system arising from skeletal muscle atrophy.

Ключові слова :

muscle soleus of rat achillotenotomy atrophy C60 fullerene biomechanical and biochemical parameters of skeletal muscle contraction

Галузі знань та спеціальності :

09 Біологія

Галузі науки і техніки (FOS) :

Біологічні науки

Файл(и) :

Завантажити

Формат :

Adobe PDF

Розмір :

2.03 MB

Контрольна сума :

(MD5):e9036e7d97224bcae94377bfced7a868

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