Functionalized Derivatives of 2-azaspiro[3.3]heptane-1-carboxylic Acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic Acid for Drug Design
Тип публікації :
Стаття
Дата випуску :
2023
Автор(и) :
Kirichok, Alexander
Yegorova, Tatyana
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Том :
11
Випуск :
2
ISSN :
2312-3222
Початкова сторінка :
31
Кінцева сторінка :
38
Цитування :
[APA 7] Kirichok, A., & Yegorova, T. (2023). Functionalized Derivatives of 2-azaspiro[3.3]heptane-1-carboxylic Acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic Acid for Drug Design. French-Ukrainian Journal of Chemistry, 11(2), 31–38. https://doi.org/10.17721/fujcV11I2P31-38
[ДСТУ] Kirichok A., Yegorova T. Functionalized Derivatives of 2-azaspiro[3.3]heptane-1-carboxylic Acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic Acid for Drug Design. French-Ukrainian Journal of Chemistry. 2023. Vol. 11, no. 2. P. 31—38. DOI: 10.17721/fujcV11I2P31-38 (date of access: 25.07.2026).
2-azaspiro[3.3]heptane-1-carboxylic acid and 7-oxa-2-azaspiro[3.5]nonane-1-carboxylic acid, which had been reported as bioisoster of well-known pipecolic acid, were subjected to chemical transformations, resulting in a number of functionalized derivatives. The obtained molecules contained diversified functional groups, allowing their incorporation in bioactive compounds in versatile modes. Described synthetic approaches afforded multigram-scaled synthesis of the desired compounds with good yields, thus being applicable in drug design
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