β-gem-Difluorinated α-Spirocyclic Amines: a Thogny Way to Essential Medchem Relevant Building Blocks
Тип публікації :
Препринт
Дата випуску :
26 травня 2026 р.
Автор(и) :
Мaksym Herasymchuk
eKNUTSHIR URL :
Журнал :
ChemRxiv
Цитування :
[APA 7] Мaksym, H. (2026). β-gem-Difluorinated α-Spirocyclic Amines: a Thogny Way to Essential Medchem Relevant Building Blocks. ChemRxiv,. https://doi.org/10.26434/chemrxiv.15003940/v1
[ДСТУ] Мaksym H. β-gem-Difluorinated α-Spirocyclic Amines: a Thogny Way to Essential Medchem Relevant Building Blocks. ChemRxiv. 2026. DOI: 10.26434/chemrxiv.15003940/v1 (дата звернення: 11.09.2026).
A set of previously unavailable β-gem-difluorinated a-spirocyclic amines is elaborated from ketones via fluorination with sulfur tetrafluoride. The reason for selecting the fluorinated agent over milder ones is clearly established. The impact of the ring size in both cycloamine and carbocyclic components is determined. Multigram synthesis of diverse difluorosubstituted amines is shown, owing to the development of a scalable procedure for starting spirocyclic ketones via the DOS approach at the building block level.
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