The synthesis of angular heteroarenochromones based on 7-hydroxy-8-carbonylchromones

Shokol, T., Lozinski, O., Gorbulenko, N., Khilya, V. (2017). The synthesis of angular heteroarenochromones based on 7-hydroxy-8-carbonylchromones. French-Ukrainian Journal of Chemistry, 5(2), 68–94. https://doi.org/10.17721/fujcV5I2P68-94

The present review highlights advanced strategies to the synthesis of the chromones annulated with O- and N-containing heterocycles at C(7)-C(8) bond. Due to the prevalence of such motives in different kinds of natural flavonoids and some alkaloids, fused chromones have attracted a great deal of attention so far. On the other hand a wide range of biological activities is displayed by the compounds of this type both among naturally occurring flavonoids and their synthetic analogues. 8-Carbonyl-7-hydroxychromones proved to be versatile synthones for the synthesis of angular hetarenochromones via approach of annulation of a heterocycle to the chromone core. It also addresses the question of the biological activity of naturally occurring and fused synthetic hetarenochromones.