Fluorinated analogues of lipidic dialkynylcarbinol pharmacophores: synthesis and cytotoxicity in HCT116 cancer cells
Тип публікації :
Стаття
Дата випуску :
2019
Автор(и) :
Rullière, Pauline
Lizeaux, François
Joly, Etienne
Ballereau, Stéphanie
Gaspard, Hafida
Maraval, Valérie
Chauvin, Remi
Genisson, Yves
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Том :
7
Випуск :
1
ISSN :
2312-3222
Початкова сторінка :
1
Кінцева сторінка :
9
Цитування :
[APA 7] Rullière, P., Lizeaux, F., Joly, E., Ballereau, S., Gaspard, H., Maraval, V., Chauvin, R., & Genisson, Y. (2019). Fluorinated analogues of lipidic dialkynylcarbinol pharmacophores: synthesis and cytotoxicity in HCT116 cancer cells. French-Ukrainian Journal of Chemistry, 7(1), 1–9. https://doi.org/10.17721/fujcV7I1P1-9
[ДСТУ] Fluorinated analogues of lipidic dialkynylcarbinol pharmacophores: synthesis and cytotoxicity in HCT116 cancer cells / P. Rullière et al. French-Ukrainian Journal of Chemistry. 2019. Vol. 7, no. 1. P. 1—9. DOI: 10.17721/fujcV7I1P1-9 (date of access: 25.07.2026).
Lipidic alkynylcarbinols (LACs) have been identified as potential antitumor compounds, and a thorough understanding of their pharmacophoric environment is now required to elucidate their biological mode of action. In the dialkynylcarbinol (DAC) series, a specific study of the pharmacophore potential has been undertaken by focusing on the synthesis of three fluorinated derivatives followed by their biological evaluation. This work highlights the requirement of an electron-rich secondary carbinol center as a key structure for cytotoxicity in HCT116 cells.
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