8-(Dichloromethylene)-3,4,7,8-tetrahydro-6 H -imidazo[5,1- c ][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation
Тип публікації :
Препринт
Дата випуску :
6 лютого 2026 р.
Автор(и) :
Oleh Shablykin
Yurii Kornii
Kateryna R Bondarenko
Svitlana V Shishkina
Andrii V Kozytskyi
Olga V. Shablykina
eKNUTSHIR URL :
Цитування :
[APA 7] Oleh, S., Yurii, K., Kateryna, R. B., Svitlana, V. S., Andrii, V. K., & Olga, V. S. (2026). 8-(Dichloromethylene)-3,4,7,8-tetrahydro-6 H -imidazo[5,1- c ][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation. https://doi.org/10.3762/bxiv.2026.7.v1
[ДСТУ] 8-(Dichloromethylene)-3,4,7,8-tetrahydro-6 H -imidazo[5,1- c ][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation / S. Oleh та ін. 2026. DOI: 10.3762/bxiv.2026.7.v1 (дата звернення: 11.09.2026).
Through cyclization of 4-(dichloromethylene)-5-(aminosulfonylimino)imidazolidin-2-ones by formaldehyde action series of 8-(dichloromethylene)-3,4,7,8-tetrahydro-6 H -imidazo[5,1- c ][1,2,4,6]thiatriazin-6-one 2,2-dioxides were synthesized. Their structure parameters were discovered by NMR experiments and X-Ray analysis. The separate products (with allyl, carbethoxymethyl, 2- N -Boc-aminoethyl, 2-( N -Boc- N -isopropoxymethylamino)ethyl substituents in position 3) demonstrated high antiproliferative activity
Файл(и) :![Ескіз]()
Вантажиться...
Формат :
Adobe PDF
Розмір :
627.9 KB
Контрольна сума :
(MD5):98fa4c35b93e13a1e102892e31f6fe15
Якщо не вказано інше, ця робота розповсюджується на умовах ліцензії Attribution 4.0 International