Compositions of Anticancer Drug with Micellar Nanocarriers and Their Cytotoxicity

Kunitskaya, Larisa; Zheltonozhskaya, Tatyana; Stoika, Rostyslav; Klymchuk, Dmytro

doi:10.17721/fujcV5I2P103-120

Compositions of Anticancer Drug with Micellar Nanocarriers and Their Cytotoxicity

Тип публікації :

Стаття

Дата випуску :

2017

Автор(и) :

Kunitskaya, Larisa

Zheltonozhskaya, Tatyana

Stoika, Rostyslav

Klymchuk, Dmytro

Мова основного тексту :

Англійська

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/25548

DOI :

10.17721/fujcV5I2P103-120

Журнал :

French-Ukrainian Journal of Chemistry

Том :

5

Випуск :

2

ISSN :

2312-3222

Початкова сторінка :

103

Кінцева сторінка :

120

Цитування :

[APA 7] Kunitskaya, L., Zheltonozhskaya, T., Stoika, R., & Klymchuk, D. (2017). Compositions of Anticancer Drug with Micellar Nanocarriers and Their Cytotoxicity. French-Ukrainian Journal of Chemistry, 5(2), 103–120. https://doi.org/10.17721/fujcV5I2P103-120

[ДСТУ] Compositions of Anticancer Drug with Micellar Nanocarriers and Their Cytotoxicity / L. Kunitskaya et al. French-Ukrainian Journal of Chemistry. 2017. Vol. 5, no. 2. P. 103—120. DOI: 10.17721/fujcV5I2P103-120 (date of access: 18.07.2026).

Asymmetric diblock (DBC) and triblock (TBC) copolymers contained biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) or its monomethyl ether (MEPEO-b-PAAm), and also partially hydrolyzed triblock copolymer derivative (TBChydr) were used to create micelles of a special type. The micelles obtained are characterized by small CMCs and large values of the Gibbs micellization energy, thus indicating a high stability of DBC, TBC and TBChydr micelles in aqueous solutions and the capabilities of their use to encapsulate and deliver poorly soluble and/or toxic drugs in living organism. Morphological features and size of DBC and TBC micelles were determined by TEM. The electron images demonstrated spherical micelles of a polymolecular type, monomolecular type and separate micelle aggregates. TBC and TBChydr micelles were used to examine in vitro anticancer activity of their compositions with doxorubicin (Dox). The created micelle systems showed the enhanced cytotoxicity as compared to individual Dox against murine leukemia cells of L1210 line, murine transformed fibroblasts of L929 line and human T-leukemia cells of Jurkat line and allow to achieve a high efficacy at low Dox concentrations (0,1÷3 µg·cm-3) that opens the great prospects for essential decrease in drug dose at chemotherapy.

Ключові слова :

micelles morphology block copolymers doxorubicin cytotoxicity

Файл(и) :

Формат :

Adobe PDF

Розмір :

1.76 MB

Контрольна сума :

(MD5):e2d2a1c8b53bf60b995f6fbd4acf4c24

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