A modular approach to functionalized azetidines. Preparation of a bioactive Ciprofloxacine analogue.

Yarema Galushchak; Yeva Shevchenko; Andrii Slobodianyk; Roman Kotsiubchyk; Tibor Soós; Svitlana Bondaruk; Galeb Al-Maali; Pavel K. Mykhailiuk

doi:10.26434/chemrxiv.15002028/v1

A modular approach to functionalized azetidines. Preparation of a bioactive Ciprofloxacine analogue.

Тип публікації :

Препринт

Дата випуску :

15 квітня 2026 р.

Автор(и) :

Yarema Galushchak

Yeva Shevchenko

Andrii Slobodianyk

Roman Kotsiubchyk

Tibor Soós

Svitlana Bondaruk

Galeb Al-Maali

Pavel K. Mykhailiuk

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/34233

DOI :

10.26434/chemrxiv.15002028/v1

Журнал :

ChemRxiv

Цитування :

[APA 7] Yarema, G., Yeva, S., Andrii, S., Roman, K., Tibor, S., Svitlana, B., Galeb, A., & Pavel, K. M. (2026). A modular approach to functionalized azetidines. Preparation of a bioactive Ciprofloxacine analogue. ChemRxiv,. https://doi.org/10.26434/chemrxiv.15002028/v1

[ДСТУ] A modular approach to functionalized azetidines. Preparation of a bioactive Ciprofloxacine analogue. / G. Yarema та ін. ChemRxiv. 2026. DOI: 10.26434/chemrxiv.15002028/v1 (дата звернення: 11.09.2026).

In 1924, Bruylants reported a reaction between aminonitriles (from ketones) and organomagnesium compounds. During the past 100 years, all possible ketones have been successfully used in this reaction except for one – N-Boc azetidinone. Here we report why that is and how to solve that problem.

Якщо не вказано інше, ця робота розповсюджується на умовах ліцензії Attribution 4.0 International