Spectroscopic Studies on the Interaction Between Novel Antiviral Drug Favipiravir and Serum Albumins

Тип публікації :
Стаття
Дата випуску :
2020
Автор(и) :
Kashutskуy, Sergey
Мова основного тексту :
Англійська
eKNUTSHIR URL :
DOI :
Журнал :
Том :
8
Випуск :
2
ISSN :
2312-3222
Початкова сторінка :
93
Кінцева сторінка :
103
Цитування :
[APA 7] Kashutskуy, S. (2020). Spectroscopic Studies on the Interaction Between Novel Antiviral Drug Favipiravir and Serum Albumins. French-Ukrainian Journal of Chemistry, 8(2), 93–103. https://doi.org/10.17721/fujcV8I2P93-103
[ДСТУ] Kashutskуy S. Spectroscopic Studies on the Interaction Between Novel Antiviral Drug Favipiravir and Serum Albumins. French-Ukrainian Journal of Chemistry. 2020. Vol. 8, no. 2. P. 93—103. DOI: 10.17721/fujcV8I2P93-103 (date of access: 18.07.2026).
Under physiological conditions, in vitro interaction between favipiravir (FAV) and serum albumins (BSA/HSA) was investigated at excitation wavelength 280 nm and at different temperatures (298 K, 313 K) by fluorescence emission spectroscopy. The hydrogen bond, van der Waals forces and electrostatic interaction plays a major role in stabilizing the complex; the binding constants KA at different temperatures were calculated. The distance r between donor (BSA/HSA) and acceptor (FAV) was obtained according to fluorescence resonance energy transfer (1.55/1.90 nm for BSA/HSA-FAV systems). The effect of FAV on the conformation of BSA/HSA was analyzed using synchronous fluorescence spectroscopy and UV/vis absorption spectroscopy.
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