Study of the Antioxidant Activity of Synthetic 3-hydroxyflavone Derivatives by DPPH and Hydrogen Peroxide Methods

Khdera, Hadi; Saad, Sawsan; Moustapha, Aoula; Kandil, Farouk

doi:10.17721/fujcV11I2P19-30

Study of the Antioxidant Activity of Synthetic 3-hydroxyflavone Derivatives by DPPH and Hydrogen Peroxide Methods

Тип публікації :

Стаття

Дата випуску :

2023

Автор(и) :

Khdera, Hadi

Saad, Sawsan

Moustapha, Aoula

Kandil, Farouk

Мова основного тексту :

Англійська

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/25353

DOI :

10.17721/fujcV11I2P19-30

Журнал :

French-Ukrainian Journal of Chemistry

Том :

11

Випуск :

2

ISSN :

2312-3222

Початкова сторінка :

19

Кінцева сторінка :

30

Цитування :

[APA 7] Khdera, H., Saad, S., Moustapha, A., & Kandil, F. (2023). Study of the Antioxidant Activity of Synthetic 3-hydroxyflavone Derivatives by DPPH and Hydrogen Peroxide Methods. French-Ukrainian Journal of Chemistry, 11(2), 19–30. https://doi.org/10.17721/fujcV11I2P19-30

[ДСТУ] Study of the Antioxidant Activity of Synthetic 3-hydroxyflavone Derivatives by DPPH and Hydrogen Peroxide Methods / H. Khdera et al. French-Ukrainian Journal of Chemistry. 2023. Vol. 11, no. 2. P. 19—30. DOI: 10.17721/fujcV11I2P19-30 (date of access: 25.07.2026).

Flavonoids have good efficacy as antioxidants due to their ability to scavenge free radicals within cells. In our previous study, synthetic flavonoid derivatives (A2-A13) were prepared in vitro through condensation, oxidative cyclization, alkylation and esterification reactions. The antioxidant activity of the alkyl and esterified derivatives of the flavonoid compound (A2) 3-hydroxy-2-(4-[dimethylamino]phenyl) benzo-4-pyrone was studied by two methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical inhibition method and inhibition of hydrogen peroxide (H2O2) and compared to the activity of standard antioxidant compounds, ascorbic acid and quercetin. The flavonoids (prepared samples) A2, A5, and A7 showed high activity approaching that of ascorbic acid and quercetin as well-known antioxidants. As for the compounds (A3, A6, A8, A9, A10, A11, A12, A13), which contain an -OH enol group, a benzyl group, and a chlorine group and the acetate group, its effectiveness has decreased significantly.

Ключові слова :

flavonol antioxidants quercetin DPPH hydrogen peroxide

Файл(и) :

Завантажити

Формат :

Adobe PDF

Розмір :

1006.96 KB

Контрольна сума :

(MD5):90dfac1f2ac4aded2657272d5cbe5eb2

Якщо не вказано інше, ця робота розповсюджується на умовах ліцензії Creative Commons Attribution 4.0 International