Modified creatine greatly increases the performance of skeletal and smooth muscles
Тип публікації :
Стаття
Дата випуску :
березень 2025 р.
Автор(и) :
Soloviev, Anatoly
a Department for Pharmacology of Cellular Signal Systems and Experimental Therapeutics, Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine
Kozlovsky Vadym
LLC “MEDIVALEX”
Taras Shevchenko National University of Kyiv
Sydorenko Vadym
a Department for Pharmacology of Cellular Signal Systems and Experimental Therapeutics, Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine
Monchak Igor
a Department for Pharmacology of Cellular Signal Systems and Experimental Therapeutics, Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine
Vdovenko Natalia
Department of Medical and Biological Disciplines, State Scientific Research Institute of Physical Culture and Sports
Maidaniuk Olena
d Department of Medical and Biological Disciplines, State Scientific Research Institute of Physical Culture and Sports
Fetyukhin Volodymyr
I.F. Lab, LLC, Life Chemicals Inc. Distributor
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Журнал :
Biochemistry and Biophysics Reports
Том :
41
ISSN :
2405-5808
Цитування :
[APA 7] Soloviev, A., Kozlovsky, V., Nozdrenko, D., Sydorenko, V., Monchak, I., Vdovenko, N., Maidaniuk, O., & Fetyukhin, V. (2025). Modified creatine greatly increases the performance of skeletal and smooth muscles. Biochemistry and Biophysics Reports, 41. https://doi.org/10.1016/j.bbrep.2025.101934
[ДСТУ] Modified creatine greatly increases the performance of skeletal and smooth muscles / A. Soloviev et al. Biochemistry and Biophysics Reports. 2025. Vol. 41. DOI: 10.1016/j.bbrep.2025.101934 (date of access: 25.07.2026).
Creatine is a nitrogen-containing carboxylic acid and a main component of phosphocreatine. In recent years, creatine is considered as a component of dietary nutrition, to improve the efficiency of physical activity and increase muscle mass of athletes and older people. Creatine has been shown to be able restore cardiac
contractility impairment after myocardial infarction. However, as muscle cells do not synthesise creatine, the efficiency of creatine depends on its transmembrane transport. In our study, we evaluated the effect of «ProCreatine» (ProCr), a novel membrane transporter-independent creatine modification on fatigability of the rat gastrocnemius muscle and portal vein smooth muscle using fa tigue stimulation pools. Mechanokinetic and biomechanical markers of fatigue in muscles to maintain the level of isometric tension induced by field electrical stimulation were examined. The results indicate that administration of ProCr to skeletal muscle significantly increases maximal force output, integrated muscle contractile force and significantly increases muscle productivity. We observed positive changes in all studied biochemical indices of fatigue. In addition, ProCr increases the duration of sustaining a constant level of isometric contraction in portal vein smooth muscle caused by electrical stimulation by 6 fold. Regular creatine in the same dose had no sig nificant effect on these parameters neither in skeletal nor in smooth muscles. The data obtained suggest the possibility of using ProCr as a therapeutic agent capable of reducing and correcting pathological conditions of the muscular system that arise during the processes of fatigue in skeletal muscles and smooth muscles of hollow organs.
contractility impairment after myocardial infarction. However, as muscle cells do not synthesise creatine, the efficiency of creatine depends on its transmembrane transport. In our study, we evaluated the effect of «ProCreatine» (ProCr), a novel membrane transporter-independent creatine modification on fatigability of the rat gastrocnemius muscle and portal vein smooth muscle using fa tigue stimulation pools. Mechanokinetic and biomechanical markers of fatigue in muscles to maintain the level of isometric tension induced by field electrical stimulation were examined. The results indicate that administration of ProCr to skeletal muscle significantly increases maximal force output, integrated muscle contractile force and significantly increases muscle productivity. We observed positive changes in all studied biochemical indices of fatigue. In addition, ProCr increases the duration of sustaining a constant level of isometric contraction in portal vein smooth muscle caused by electrical stimulation by 6 fold. Regular creatine in the same dose had no sig nificant effect on these parameters neither in skeletal nor in smooth muscles. The data obtained suggest the possibility of using ProCr as a therapeutic agent capable of reducing and correcting pathological conditions of the muscular system that arise during the processes of fatigue in skeletal muscles and smooth muscles of hollow organs.
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Галузі знань та спеціальності :
09 Біологія
Галузі науки і техніки (FOS) :
Біологічні науки
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