Analysis of Biomechanical Parameters of Muscle Soleus Contraction and Blood Biochemical Parameters in Rat with Chronic Glyphosate Intoxication and Therapeutic Use of C60 Fullerene
Тип публікації :
Стаття
Дата випуску :
2021
Автор(и) :
Taras Shevchenko National University of Kyiv
Abramchuk, Olga
Lesya Ukrainka Volyn National University
Prylutska, Svitlana
Department of Biophysics and Medical Informatic, Taras Shevchenko National University of Kyiv
Vygovska Oksana
Bogomolets National Medical University of Kyiv
Soroca Vasil
Department of Biophysics and Medical Informatic, Taras Shevchenko National University of Kyiv
Taras Shevchenko National University of Kyiv
Khrapatyi, Sergii
Interregional Academy of Personnel Management, Odessa I.I.Mechnikov National University, Taras Shevchenko National University of Kyiv
Taras Shevchenko National University of Kyiv
Scharff, Peter
Technische Universität Ilmenau
Ritter Uwe
Institute of Chemistry and Biotechnology, Technical University of Ilmenau
Мова основного тексту :
Англійська
eKNUTSHIR URL :
DOI :
Журнал :
International Journal of Molecular Sciences
Том :
22
Випуск :
9
ISSN :
1422-0067
Початкова сторінка :
1
Кінцева сторінка :
11
Цитування :
[APA 7] Nozdrenko, D., Abramchuk, O., Prylutska, S., Vygovska, O., Soroca, V., Bogutska, K., Khrapatyi, S., Prylutskyy, Y., Scharff, P., & Ritter, U. (2021). Analysis of Biomechanical Parameters of Muscle Soleus Contraction and Blood Biochemical Parameters in Rat with Chronic Glyphosate Intoxication and Therapeutic Use of C60 Fullerene. International Journal of Molecular Sciences, 22(9), 1–11. https://doi.org/10.3390/ijms22094977
[ДСТУ] Analysis of Biomechanical Parameters of Muscle Soleus Contraction and Blood Biochemical Parameters in Rat with Chronic Glyphosate Intoxication and Therapeutic Use of C60 Fullerene / D. Nozdrenko et al. International Journal of Molecular Sciences. 2021. Vol. 22, no. 9. P. 1—11. DOI: 10.3390/ijms22094977 (date of access: 25.07.2026).
The widespread use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites in food for human consumption and thus pose a threat to human health. It has been found that glyphosate reduces energy metabolism in the brain, its amount increases in white muscle fibers. At the same time, the effect of chronic use of glyphosate on the dynamic properties of skeletal muscles remains practically unexplored. The selected biomechanical parameters (the integrated power of muscle contraction, the time of reaching the muscle contraction force its maximum value and the reduction of the force response by 50% and 25% of the initial values during stimulation) of muscle soleus contraction in rats, as well as blood biochemical parameters (the levels of creatinine, creatine phosphokinase, lactate, lactate dehydrogenase, thiobarbituric acid reactive substances, hydrogen peroxide, reduced glutathione and catalase) were analyzed after chronic glyphosate intoxication (oral administration at a dose of 10 μg/kg of animal weight) for 30 days. Water-soluble C60 fullerene, as a poweful antioxidant, was used as a therapeutic nanoagent throughout the entire period of intoxication with the above herbicide (oral administration at doses of 0.5 or 1 mg/kg). The data obtained show that the introduction of C60 fullerene at a dose of 0.5 mg/kg reduces the degree of pathological changes by 40–45%. Increasing the dose of C60 fullerene to 1 mg/kg increases the therapeutic effect by 55–65%, normalizing the studied biomechanical and biochemical parameters. Thus, C60 fullerenes can be effective nanotherapeutics in the treatment of glyphosate-based herbicide poisoning.
Галузі знань та спеціальності :
09 Біологія::091 Біологія та біохімія
Галузі науки і техніки (FOS) :
Біологічні науки
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18.91 MB
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