C60 Fullerene Reduces the Development of Post-Traumatic Dysfunction in Rat Soleus Muscle

Traumatic skeletal muscle injury is a complex pathology caused by high-energy trauma to muscle tissue. Previously, a positive effect was established when C60 fullerene was administered against the background of muscle ischemia, mechanical muscle injury, and other muscle dysfunctions, which probably protected the muscle tissue from damage caused by oxidative stress. Using tensiometry and biochemical analysis, the biomechanical parameters of skeletal muscle contraction and biochemical indices of the blood of rats 15 days after traumatic injury of the soleus muscle caused by myocyte destruction by compression were studied. The intraperitoneal administration of C60 fullerene aqueous solution (C60FAS) in a daily dose of 1 mg/kg improved its contractile function by 28–40 ± 2% and the values of the investigated biochemical indices of the animals’ blood by 15–34 ± 2% relative to the trauma group. The obtained results indicate the potential ability of C60 fullerenes, as powerful antioxidants, to reduce the development of post-traumatic dysfunction of the soleus muscle.

Prylutskyy, Y.; Nozdrenko, D.; Motuziuk, O.; Prylutska, S.; Bogutska, K.; Abramchuk, O.; Morenko, A.; Franskevych, D.; Scharff, P.; Ritter, U. C60 Fullerene Reduces the Development of Post-Traumatic Dysfunction in Rat Soleus Muscle. Int. J. Mol. Sci. 2024, 25, 12206. https:// doi.org/10.3390/ijms252212206