C60 Fullerene Reduces the Development of Post-Traumatic Dysfunction in Rat Soleus Muscle

Prylutskyy, Yuriy; Nozdrenko, Dmytro; Motuziuk, Oleksandr; Prylutska Svitlana; Bogutska, Kateryna; Abramchuk Olga; Morenko Alevtyna; Franskevych Daria; Scharff Peter; Ritter Uwe

doi:10.3390/ijms252212206

C60 Fullerene Reduces the Development of Post-Traumatic Dysfunction in Rat Soleus Muscle

Тип публікації :

Стаття

Дата випуску :

2024

Автор(и) :

Prylutskyy, Yuriy

Taras Shevchenko National University of Kyiv

Nozdrenko, Dmytro

Taras Shevchenko National University of Kyiv

Motuziuk, Oleksandr

Lesia Ukrainka Volyn National University, Taras Shevchenko National University of Kyiv

Prylutska Svitlana

Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University

Bogutska, Kateryna

Taras Shevchenko National University of Kyiv, Taras Shevchenko National University of Kyiv:, Taras Shevchenko University of Kyiv

Abramchuk Olga

Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine

Morenko Alevtyna

Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University

Franskevych Daria

ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv

Scharff Peter

Institute of Chemistry and Biotechnology, Technical University of Ilmenau

Ritter Uwe

Institute of Chemistry and Biotechnology, Technical University of Ilmenau

Мова основного тексту :

Англійська

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/5887

DOI :

10.3390/ijms252212206

Журнал :

International Journal of Molecular Sciences

Том :

25

ISSN :

1422-0067

Початкова сторінка :

1

Кінцева сторінка :

12

Цитування :

[APA 7] Prylutskyy, Y., Nozdrenko, D., Motuziuk, O., Prylutska, S., Bogutska, K., Abramchuk, O., Morenko, A., Franskevych, D., Scharff, P., & Ritter, U. (2024). C60 Fullerene Reduces the Development of Post-Traumatic Dysfunction in Rat Soleus Muscle. International Journal of Molecular Sciences, 25, 1–12. https://doi.org/10.3390/ijms252212206

[ДСТУ] C60 Fullerene Reduces the Development of Post-Traumatic Dysfunction in Rat Soleus Muscle / Y. Prylutskyy et al. International Journal of Molecular Sciences. 2024. Vol. 25. P. 1—12. DOI: 10.3390/ijms252212206 (date of access: 25.07.2026).

Traumatic skeletal muscle injury is a complex pathology caused by high-energy trauma to muscle tissue. Previously, a positive effect was established when C60 fullerene was administered against the background of muscle ischemia, mechanical muscle injury, and other muscle dysfunctions, which probably protected the muscle tissue from damage caused by oxidative stress. Using tensiometry and biochemical analysis, the biomechanical parameters of skeletal muscle contraction and biochemical indices of the blood of rats 15 days after traumatic injury of the soleus muscle caused by myocyte destruction by compression were studied. The intraperitoneal administration of C60 fullerene aqueous solution (C60FAS) in a daily dose of 1 mg/kg improved its contractile function by 28–40 ± 2% and the values of the investigated biochemical indices of the animals’ blood by 15–34 ± 2% relative to the trauma group. The obtained results indicate the potential ability of C60 fullerenes, as powerful antioxidants, to reduce the development of post-traumatic dysfunction of the soleus muscle.

Ключові слова :

soleus muscle muscle injury C60 fullerene biomechanical and biochemical parameters

Галузі знань та спеціальності :

09 Біологія

Галузі науки і техніки (FOS) :

Біологічні науки

Файл(и) :

Завантажити

Формат :

Adobe PDF

Розмір :

2.69 MB

Контрольна сума :

(MD5):8d0150f37a1704210b5340d96847bd37

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