Phytochemical composition, antioxidant and antiproliferative activities of Rosmarinus officinalis leaves
Тип публікації :
Стаття
Дата випуску :
2020
Автор(и) :
Nassazi, Winfred
K’Owino, Isaac
Makatiani, Jacqueline
Wachira, Sabina
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Том :
8
Випуск :
2
ISSN :
2312-3222
Початкова сторінка :
150
Кінцева сторінка :
167
Цитування :
[APA 7] Nassazi, W., K’Owino, I., Makatiani, J., & Wachira, S. (2020). Phytochemical composition, antioxidant and antiproliferative activities of Rosmarinus officinalis leaves. French-Ukrainian Journal of Chemistry, 8(2), 150–167. https://doi.org/10.17721/fujcV8I2P150-167
[ДСТУ] Phytochemical composition, antioxidant and antiproliferative activities of Rosmarinus officinalis leaves / W. Nassazi et al. French-Ukrainian Journal of Chemistry. 2020. Vol. 8, no. 2. P. 150—167. DOI: 10.17721/fujcV8I2P150-167 (date of access: 25.07.2026).
Phytochemicals in Rosmarinus officinalis leaves, their total phenolic content, antioxidant potential and antiproliferative activity against human prostate (DU145), colon (CT26) and cervical (HeLa 229) cancer cells were investigated. Extraction was done separately using hexane, dichloromethane, ethyl acetate and methanol. A total of 32 compounds were identified, eight of which were reported for the first time. The highest phenolic content was 476.80 ± 0.69 µg/ml for the methanolic extract which also had the highest antioxidant activity with a minimum inhibitory concentration of 5.39 ± 0.09 mg/ml. Extracts exhibited the highest toxicity against prostate cancer cells and the least against cervical cancer cells.
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