Protective Effect of Water-Soluble C60 Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats

Nozdrenko, Dmytro; Matvienko Tetiana; Vygovska Oksana; Bogutska, Kateryna; Motuziuk, Oleksandr; Nurishchenko, Nataliya; Prylutskyy, Yuriy; Scharff, Peter; Ritter, Uwe

doi:10.3390/ijms22136812

Protective Effect of Water-Soluble C60 Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats

Тип публікації :

Стаття

Дата випуску :

2021

Автор(и) :

Nozdrenko, Dmytro

Taras Shevchenko National University of Kyiv

Matvienko Tetiana

Taras Shevchenko National University of Kyiv

Vygovska Oksana

Bogomolets National Medical University of Kyiv

Bogutska, Kateryna

Taras Shevchenko National University of Kyiv, Taras Shevchenko National University of Kyiv:, Taras Shevchenko University of Kyiv

Motuziuk, Oleksandr

Lesia Ukrainka Volyn National University, Taras Shevchenko National University of Kyiv

Nurishchenko, Nataliya

Taras Shevchenko National University of Kyiv

Prylutskyy, Yuriy

Taras Shevchenko National University of Kyiv

Scharff, Peter

Technische Universität Ilmenau

Ritter, Uwe

Мова основного тексту :

Англійська

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/5723

DOI :

10.3390/ijms22136812

Журнал :

International Journal of Molecular Sciences

Том :

22

Випуск :

13

ISSN :

1422-0067

Початкова сторінка :

1

Кінцева сторінка :

13

Цитування :

[APA 7] Nozdrenko, D., Matvienko, T., Vygovska, O., Bogutska, K., Motuziuk, O., Nurishchenko, N., Prylutskyy, Y., Scharff, P., & Ritter, U. (2021). Protective Effect of Water-Soluble C60 Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats. International Journal of Molecular Sciences, 22(13), 1–13. https://doi.org/10.3390/ijms22136812

[ДСТУ] Protective Effect of Water-Soluble C60 Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats / D. Nozdrenko et al. International Journal of Molecular Sciences. 2021. Vol. 22, no. 13. P. 1—13. DOI: 10.3390/ijms22136812 (date of access: 25.07.2026).

The biomechanical parameters of muscle soleus contraction in rats and their blood biochemical indicators after the intramuscular administration of water-soluble C60 fullerene at doses of 0.5, 1, and 2 mg/kg 1 h before the onset of muscle ischemia were investigated. In particular, changes in the contraction force of the ischemic muscle soleus, the integrated power of the muscle, the time to achieve the maximum force response, the dynamics of fatigue processes, and the parameters of the transition from dentate to smooth tetanus, levels of creatinine, creatine kinase, lactate and lactate dehydrogenase, and parameters of prooxidant–antioxidant balance (thiobarbituric acid reactive substances, hydrogen peroxide, and reduced glutathione and catalase) were analyzed. The positive therapeutic changes in the studied biomechanical and biochemical markers were revealed, which indicate the possibility of using water-soluble C60 fullerenes as effective prophylactic nanoagents to reduce the severity of pathological conditions of the muscular system caused by ischemic damage to skeletal muscles.

Ключові слова :

C60 fullerene muscle soleus of rat ischemia biomechanical and biochemical parameters

Галузі знань та спеціальності :

09 Біологія

Галузі науки і техніки (FOS) :

Біологічні науки

Файл(и) :

Завантажити

Формат :

Adobe PDF

Розмір :

17.14 MB

Контрольна сума :

(MD5):6192733738f72fe707f5494ce607dc56

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