Reaction of the α-azahetaryl-2-hydroxyacetophenones reaction with chloroacetyl chloride

Shokol, T. V., Gorbulenko, N. V., Khilya, V. P. (2013). Reaction of the α-azahetaryl-2-hydroxyacetophenones reaction with chloroacetyl chloride. French-Ukrainian Journal of Chemistry, 1(1), 10–14.

The reaction of α-azolyl-2-hydroxyacetophenones with chloroacetyl chloride in acetonitrile in the presence of pyridine resulted in 2-chloromethyl-3-azolylchromones, while both the α-(2-pyridyl) and α-(2-quinolyl) derivatives formed the products of the subsequent intramolecular cyclization with annelation of indolizine or pyrroloquinoline ring to the chromone core.