Synthesis and biological activity of 3-azahetarylchroman-4-ones

Gorbulenko, N., Shokol, T., Khilya, V. (2015). Synthesis and biological activity of 3-azahetarylchroman-4-ones. French-Ukrainian Journal of Chemistry, 3(1), 4–20. https://doi.org/10.17721/fujcV3I1P4-20

Articles reporting on the synthesis and biological activity of 3-hetarylchroman-4-ones are reviewed. The following preparative methods to 3-hetarylchroman-4-ones - nucleophilic substitution in 3-bromochroman-4-ones, cyclization of 2-hydroxy-α-hetarylacetophenones, reduction/hydrogenation of 3-azahetarylchromones, their benefits and disadvantages are described. The biological activity of 3-hetarylchromanones is also surveyed.