α-Fluoroamines: Myth or Reality?

Vadym V. Levterov; Oleh Shablykin; Oleksandr Stashkevych; Volodymyr Kokhalskyi; Vadym Konashuk; Iryna V. Sadkova; Olha Shevchuk; Petro Borysko; Pavel K Mykhailiuk

doi:10.26434/chemrxiv.10002101/v1

α-Fluoroamines: Myth or Reality?

Тип публікації :

Препринт

Дата випуску :

10 лютого 2026 р.

Автор(и) :

Vadym V. Levterov

Oleh Shablykin

Oleksandr Stashkevych

Volodymyr Kokhalskyi

Vadym Konashuk

Iryna V. Sadkova

Olha Shevchuk

Petro Borysko

Pavel K Mykhailiuk

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/34252

DOI :

10.26434/chemrxiv.10002101/v1

Журнал :

ChemRxiv

Цитування :

[APA 7] Vadym, V. L., Oleh, S., Oleksandr, S., Volodymyr, K., Vadym, K., Iryna, V. S., Olha, S., Petro, B., & Pavel, K. M. (2026). α-Fluoroamines: Myth or Reality?. ChemRxiv,. https://doi.org/10.26434/chemrxiv.10002101/v1

[ДСТУ] α-Fluoroamines: Myth or Reality? / V. L. Vadym та ін. ChemRxiv. 2026. DOI: 10.26434/chemrxiv.10002101/v1 (дата звернення: 11.09.2026).

Reality. Since 1985, scientists have been chasing aliphatic α-fluoroamines. Yet, these structures are unstable due to dehydrofluorination. In this work, we have shown that the minimal structural modification - incorporation of the CH 2 -group - of the elusive α-fluoropiperidine provides a stable α-fluoroamine. This previously nonexistent chemical compound class has been comprehensively studied, characterized, and used in a medicinal chemistry project. Dedicated to the people of Ukraine.

Якщо не вказано інше, ця робота розповсюджується на умовах ліцензії Attribution 4.0 International