Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue

Nozdrenko, Dmytro; Bogutska, Kateryna; Pampuha I. V.; Gonchar O. O.; Abramchuk O. M.; Prylutskyy, Yuriy

doi:10.15407/ubj93.04.093

Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue

Тип публікації :

Стаття

Дата випуску :

13 вересня 2021 р.

Автор(и) :

Nozdrenko, Dmytro

Taras Shevchenko National University of Kyiv

Bogutska, Kateryna

Taras Shevchenko National University of Kyiv, Taras Shevchenko National University of Kyiv:, Taras Shevchenko University of Kyiv

Pampuha I. V.

Taras Shevchenko National University of Kyiv

Gonchar O. O.

Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine

Abramchuk O. M.

Lesya Ukrainka Volyn National University

Prylutskyy, Yuriy

Taras Shevchenko National University of Kyiv

Мова основного тексту :

Англійська

eKNUTSHIR URL :

https://ir.library.knu.ua/handle/15071834/5890

DOI :

10.15407/ubj93.04.093

Журнал :

The Ukrainian Biochemical Journal

Том :

93

Випуск :

4

ISSN :

2409-4943

Початкова сторінка :

93

Кінцева сторінка :

102

Цитування :

[APA 7] Nozdrenko, D., Bogutska, K., Pampuha, I. V., Gonchar, O. O., Abramchuk, O. M., & Prylutskyy, Y. (2021). Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue. The Ukrainian Biochemical Journal, 93(4), 93–102. https://doi.org/10.15407/ubj93.04.093

[ДСТУ] Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue / D. Nozdrenko et al. The Ukrainian Biochemical Journal. 2021. Vol. 93, no. 4. P. 93—102. DOI: 10.15407/ubj93.04.093 (date of access: 25.07.2026).

The protective effect of water-soluble C60 fullerenes on the development of slow and rapid fatigue of rat skeletal muscles was analyzed. It was found that the reduction of muscle contraction force (muscle soleus) by 50% of the initial values is almost twice as slow as stimulation with a frequency of 1 Hz (slow muscle fatigue) than with 2 Hz (rapid muscle fatigue) stimulation after intramuscular injection of C60 fullerenes (dose 0.5 mg/kg). There is a clear tendency to decrease the values of biochemical parameters of the blood of animals with the therapeutic effect of water-soluble C60 fullerenes by approximately 45-60% and 35-40% with the development of slow and rapid muscle fatigue, respectively. Thus, C60 fullerenes, as powerful antioxidants, are able to efficiently affect the prooxidant-antioxidant homeostasis of muscle tissue and thus help maintain its normal physiological state.

Ключові слова :

skeletal muscle fatigue biochemical and tensometric analysis C60 fullerene

Галузі знань та спеціальності :

09 Біологія::091 Біологія та біохімія

Галузі науки і техніки (FOS) :

Біологічні науки

Файл(и) :

Завантажити

Формат :

Adobe PDF

Розмір :

1.16 MB

Контрольна сума :

(MD5):186f988fc48b090eebf4d37175679100

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

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