Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue

Nozdrenko, D. M., Bogutska, K. I., Pampuha, I. V., Gonchar, O. O., Abramchuk, O. M., & Prylutskyy, Y. I. (2021). Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue. The Ukrainian Biochemical Journal, 93(4), 93–102. https://doi.org/10.15407/ubj93.04.093

The protective effect of water-soluble C60 fullerenes on the development of slow and rapid fatigue of rat skeletal muscles was analyzed. It was found that the reduction of muscle contraction force (muscle soleus) by 50% of the initial values is almost twice as slow as stimulation with a frequency of 1 Hz (slow muscle fatigue) than with 2 Hz (rapid muscle fatigue) stimulation after intramuscular injection of C60 fullerenes (dose 0.5 mg/kg). There is a clear tendency to decrease the values of biochemical parameters of the blood of animals with the therapeutic effect of water-soluble C60 fullerenes by approximately 45-60% and 35-40% with the development of slow and rapid muscle fatigue, respectively. Thus, C60 fullerenes, as powerful antioxidants, are able to efficiently affect the prooxidant-antioxidant homeostasis of muscle tissue and thus help maintain its normal physiological state.