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  1. Головна
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  4. The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization
 
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The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

Журнал/Серія :
Studia Biologica
Том :
18
Випуск :
1
ISSN :
1996-4536 / 2311-0783
Початкова сторінка :
43
Кінцева сторінка :
56
Дата випуску :
2024
Автор(и) :
Nozdrenko, Dmytro 
Taras Shevchenko National University of Kyiv
Wang Nan
Lesya Ukrainka Volyn National University
Motuziuk, Oleksandr
Taras Shevchenko National University of Kyiv, Lesia Ukrainka Volyn National University
Prylutska Svitlana
National University of Life and Environmental Science of Ukraine
Vygovska Oksana
Bogomolets National Medical University of Kyiv
Bogutska, Kateryna 
Taras Shevchenko National University of Kyiv
Dmytrotsa Оlena
Lesya Ukrainka Volyn National University
Lynchak, Oksana 
Taras Shevchenko National University of Kyiv
Prylutskyy, Yuriy 
Taras Shevchenko National University of Kyiv
Анотація :
Background. It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism, the most significant of which are disturbances in the dynamics of muscle contraction. A positive effect of biocompatible water-soluble C60 fullerenes on the contraction parameters of damaged muscles has been established. In addition, administration of C60 fullerene aqueous solution during chronic alcoholization of rats protects muscle tissue from damage caused by oxidative stress. Materials and Methods. Biomechanical parameters such as the values of the minimum and maximum contraction force and the muscle force impulse were evaluated using tensometry. The blood levels of creatine phosphokinase and lactate dehydrogenase, creatinine and lactate as well as the level of oxidative processes in muscle tissue of experimental animals (content of hydrogen peroxide, activity of catalase, glutathione peroxidase and superoxide dismutase) as markers of muscle damage were determined using methods of biochemical analysis. Results. The C60 fullerene aqueous solution effect on the skeletal muscle contraction dynamics in rats after chronic alcoholization for 9 months and cessation of alcohol consumption for 1 month was investigated. It was established that water-soluble C60 fullerenes (daily dose of 1 mg/kg) reduce the effects of chronic alcoholization by 35–40±2 % on the studied biomechanical parameters and by 20±1 % on the studied biochemical parameters compared to the group of alcoholized animals, thus increasing the energy capabilities of the muscular system. Conclusions. The obtained data indicate a pronounced protective effect of C60 fullerenes on the muscle soleus contraction dynamics during the development of alcoholic myopathy, which opens up the potential possibility of their use for the prevention and correction of miotic damage.
Цитування :
Nozdrenko, D., Nan, W., Motuziuk, O., Prylutska, S., Vygovska, O., Bogutska, K., Dmytrotsa, O., Lynchak, O., & Prylutskyy, Yu. (2024). The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization. Studia Biologica, 18(1), 43–56. doi:10.30970/sbi.1801.755
Ключові слова :

muscle soleus

alcoholization

C60 fullerene

biomechanical paramet...

biochemical indicator...

eKNUTSHIR URL :
https://ir.library.knu.ua/handle/15071834/5860
DOI :
10.30970/sbi.1801.755
Файл(и) :
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