On terminal alkynylcarbinols and derivatization thereof
Тип публікації :
Стаття
Дата випуску :
2015
Автор(и) :
Listunov, Dymytrii
Maraval, Valérie
Saffon-Merceron, Nathalie
Mallet-Ladeira, Sonia
Voitenko, Zoia
Volovenko, Yulian
Génisson, Yves
Chauvin, Remi
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Том :
3
Випуск :
1
ISSN :
2312-3222
Початкова сторінка :
21
Кінцева сторінка :
28
Цитування :
[APA 7] Listunov, D., Maraval, V., Saffon-Merceron, N., Mallet-Ladeira, S., Voitenko, Z., Volovenko, Y., Génisson, Y., & Chauvin, R. (2015). On terminal alkynylcarbinols and derivatization thereof. French-Ukrainian Journal of Chemistry, 3(1), 21–28. https://doi.org/10.17721/fujcV3I1P21-28
[ДСТУ] On terminal alkynylcarbinols and derivatization thereof / D. Listunov et al. French-Ukrainian Journal of Chemistry. 2015. Vol. 3, no. 1. P. 21—28. DOI: 10.17721/fujcV3I1P21-28 (date of access: 25.07.2026).
The chemistry of three prototypes of secondary alkynylcarbinols (ACs), recently highlighted as challenging targets in anti-tumoral medicinal chemistry, is further documented by results on n-alkyl, alkynyl and alkenyl representatives. The N-naphthyl carbamate of an n-butyl-AC is thus characterized by X-ray crystallography. A novel dialkynylcarbinol (DAC) with synthetic potential is described, namely the highly dissymmetrical triisopropylsilyl-protected version of diethynylmethanol. The latter is shown to act as a dipolarophile in a selective Huisgen reaction with benzyl azide under CuAAC click conditions, giving an alkenyl-AC, where the alkene unsaturation is embedded in a 1,4-disubstituted 1,2,3-triazole ring, as confirmed by X-ray crystallography.Supplementary information (CIF file)
Файл(и) :![Ескіз]()
Вантажиться...
Формат :
Adobe PDF
Розмір :
574.72 KB
Контрольна сума :
(MD5):b59aeae8222e0e2a1f6b12492571371b
Якщо не вказано інше, ця робота розповсюджується на умовах ліцензії Creative Commons Attribution 4.0 International