Characteristics of iron-dependent parameters of donors under the presence of anti-SARS-CoV-2 IgG in the blood

COVID-19 differs from other respiratory diseases in that it can cause an acute inflammatory reaction following widespread systemic complications in organisms. First, the inflammatory process causes an increase in the concentration of C-reactive protein (CRP), which could be a prognostic biomarker in patients with COVID-19. In addition, some clinical data were used to determine changes in the concentrations of ferritin and transferrin. Our study aimed to establish a relationship between the inflammatory process and iron-dependent parameters, as changes in concentration could lead to pathological status in the post-COVID-19 period. People suffered from COVID-19 with different titers of anti-SARS-CoV-2 IgG in the blood participated in our experiment. It was established that the maximal concentration of CRP and ferritin was characterized for the donor group with a titer of anti-SARS-CoV-2 IgG 95 ± 5 Index (S/C) following the development of inflammatory anemia. Moreover, it was discovered that the group with a minimal titer of anti-SARS-CoV-2 IgG was characterized by the maximal concentration of transferrin, leading to the destruction of iron transport. Due to the acute inflammatory process and damage to the transport and storage of iron by transferrin and ferritin, the iron deficit could destroy the functioning of the muscle system. There was a change in the concentration of creatine kinase in the donor group with a titer of anti-SARS-CoV-2 IgG of 95 ± 5 Index (S/C). The study showed that infection with the SARS-CoV-2 virus in the body often leads to the development of acute inflammatory reactions, resulting in iron transport and storage processes, which cause pathological processes in the post-COVID-19 period.

Characteristics of iron-dependent parameters of donors under the presence of anti-SARS-CoV-2 IgG in the blood / D. Krenytska та ін. Вісник Київського національного університету імені Тараса Шевченка. Біологія. 2022. Вип. 4(91). С. 10-14.