The mechanism of dermatotropic actions of nanocrystalline cerium dioxide
Тип публікації :
Дисертація
Дата випуску :
2019
Автор(и) :
Amiri Gorzoddini Arefeh
Науковий(і) керівник(и)/редактор(и) :
Верещака Володимир Валентинович
Мова основного тексту :
en_US
en_US
eKNUTSHIR URL :
Цитування :
[APA 7] Amiri, G. A. (2019). The mechanism of dermatotropic actions of nanocrystalline cerium dioxide. [Doctoral dissertation, Київський національний університет імені Тараса Шевченка]. eKNUTSHIR. https://ir.library.knu.ua/handle/123456789/447
[ДСТУ] Amiri G. A. The mechanism of dermatotropic actions of nanocrystalline cerium dioxide : doctoral dissertation : 09 Біологія. Kyiv, 2019. URL: https://ir.library.knu.ua/handle/123456789/447 (date of access: 18.07.2026).
The work is devoted to the study of dermatotropic effects of nanoceria with its pharmaceutical compositions in wound healing process on rats with full-thickness wound model.
It has been established that at all times of observation, the area of full-thickness wound under the action of the nanocrystalline cerium dioxide (Nanoceria)-based pharmacological composition was significantly less than the wound area without application of the composition. On the 6th, 9th and 20th day of experiment nanoceria-based composition treated wounds areas were by 20,1% (p<0.05), 37,5% (p<0.05) and by 34.0% (p<0.05) accordance decreased in comparison with control. Complete epithelialization of the wounds under the influence of the pharmacological composition occurred more quickly for 3 days (in intact group of rats it took 23.0±0.8 for complete wound closure and 20.0±0.5 for experimental group).
It has been established that a pharmacological composition containing 0.05% Nanoceria dissolved in 0.5% carbopol has a bactericidal effect on the test cultures of Staphylococcus epidermis, Staphylococcus aureus and Pseudomonas aeruginosa, and the fungistatic effect on the test culture of yeast fungi of the genus Candida.
It has been established that at all times of observation, the area of full-thickness wound under the action of the nanocrystalline cerium dioxide (Nanoceria)-based pharmacological composition was significantly less than the wound area without application of the composition. On the 6th, 9th and 20th day of experiment nanoceria-based composition treated wounds areas were by 20,1% (p<0.05), 37,5% (p<0.05) and by 34.0% (p<0.05) accordance decreased in comparison with control. Complete epithelialization of the wounds under the influence of the pharmacological composition occurred more quickly for 3 days (in intact group of rats it took 23.0±0.8 for complete wound closure and 20.0±0.5 for experimental group).
It has been established that a pharmacological composition containing 0.05% Nanoceria dissolved in 0.5% carbopol has a bactericidal effect on the test cultures of Staphylococcus epidermis, Staphylococcus aureus and Pseudomonas aeruginosa, and the fungistatic effect on the test culture of yeast fungi of the genus Candida.
Галузі знань та спеціальності :
09 Біологія
091 Біологія та біохімія
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Формат :
Adobe PDF
Розмір :
2.34 MB
Контрольна сума :
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