The mechanism of dermatotropic actions of nanocrystalline cerium dioxide

Amiri Gorzoddini Arefeh. The mechanism of dermatotropic actions of nanocrystalline cerium dioxide : diss. ... candidate of biol. sciences : 03.00/04 - biochemistry / Amiri Gorzoddini Arefeh. - Kyiv, 2019. - 137 р.

The work is devoted to the study of dermatotropic effects of nanoceria with its pharmaceutical compositions in wound healing process on rats with full-thickness wound model.
It has been established that at all times of observation, the area of full-thickness wound under the action of the nanocrystalline cerium dioxide (Nanoceria)-based pharmacological composition was significantly less than the wound area without application of the composition. On the 6th, 9th and 20th day of experiment nanoceria-based composition treated wounds areas were by 20,1% (p<0.05), 37,5% (p<0.05) and by 34.0% (p<0.05) accordance decreased in comparison with control. Complete epithelialization of the wounds under the influence of the pharmacological composition occurred more quickly for 3 days (in intact group of rats it took 23.0±0.8 for complete wound closure and 20.0±0.5 for experimental group).
It has been established that a pharmacological composition containing 0.05% Nanoceria dissolved in 0.5% carbopol has a bactericidal effect on the test cultures of Staphylococcus epidermis, Staphylococcus aureus and Pseudomonas aeruginosa, and the fungistatic effect on the test culture of yeast fungi of the genus Candida.