The mechanism of dermatotropic actions of nanocrystalline cerium dioxide

The work is devoted to the study of dermatotropic effects of nanoceria with its pharmaceutical compositions in wound healing process on rats with full-thickness wound model.
It has been established that at all times of observation, the area of full-thickness wound under the action of the nanocrystalline cerium dioxide (Nanoceria)-based pharmacological composition was significantly less than the wound area without application of the composition. On the 6th, 9th and 20th day of experiment nanoceria-based composition treated wounds areas were by 20,1% (p<0.05), 37,5% (p<0.05) and by 34.0% (p<0.05) accordance decreased in comparison with control. Complete epithelialization of the wounds under the influence of the pharmacological composition occurred more quickly for 3 days (in intact group of rats it took 23.0±0.8 for complete wound closure and 20.0±0.5 for experimental group).
It has been established that a pharmacological composition containing 0.05% Nanoceria dissolved in 0.5% carbopol has a bactericidal effect on the test cultures of Staphylococcus epidermis, Staphylococcus aureus and Pseudomonas aeruginosa, and the fungistatic effect on the test culture of yeast fungi of the genus Candida.

Amiri Gorzoddini Arefeh. The mechanism of dermatotropic actions of nanocrystalline cerium dioxide : diss. ... candidate of biol. sciences : 03.00/04 - biochemistry / Amiri Gorzoddini Arefeh. - Kyiv, 2019. - 137 р.