Histological Study of the Features of Angiogenesis Lewis Lung Carcinoma under the Influence of Mesenchymal Stem Cells of the Placenta

Ostrovska, G. V., Garmanchuk, L. V., Stepanov, Y. V., Bukreieva, T. V., & Khranovska, N. M. (2024). Histological Study of the Features of Angiogenesis Lewis Lung Carcinoma under the Influence of Mesenchymal Stem Cells of the Placenta. Cytology and Genetics, 58(3), 214–224. doi:10.3103/s0095452724030095

Morphological features of angiogenesis processes in Lewis lung carcinoma (LLC) regrowth tumors were investigated and analyzed during their independent development and under the influence of cryopreserved mesenchymal stem cells of the human placenta (hP-MSC) under different administration conditions. In LLC tumors, an earlier (day 1) onset of angiogenesis was revealed, with pronounced extramedullary hematopoiesis and the formation of unstructured provascular structures. It was shown that, in general, hP-MSC provides a more structurally perfect angiogenesis in the tumor, with the formation on the 15th day of vascular formations surrounded by a cell wall formed from the cells of the tumor itself. Different morphological forms of neoangiogenesis were detected both in LLC tumors that develop independently, and with different methods of hP-MSC administration—with simultaneous inoculation with tumor cells and with systemic (intravenous) administration. However, more active neoangiogenesis in LLC tumors was noted with systemic intravenous administration of hP-MSC.