Direct green synthesis of benzimidazoles from ortho-nitroanilines and ortho-dinitrobenzenes promoted by sulfur oxo salts.
Тип публікації :
Препринт
Дата випуску :
22 червня 2026 р.
Автор(и) :
Volodymyr Puskov
Serhii B. Babii
Tetiana V. Druzhenko
Alexander Yu. Lyapunov
Dmytro M. Volochnyuk
Sergey V. Ryabukhin
eKNUTSHIR URL :
Журнал :
ChemRxiv
Цитування :
[APA 7] Volodymyr, P., Serhii, B. B., Tetiana, V. D., Alexander, Y. L., Dmytro, M. V., & Sergey, V. R. (2026). Direct green synthesis of benzimidazoles from ortho-nitroanilines and ortho-dinitrobenzenes promoted by sulfur oxo salts. ChemRxiv,. https://doi.org/10.26434/chemrxiv.15005066/v1
[ДСТУ] Direct green synthesis of benzimidazoles from ortho-nitroanilines and ortho-dinitrobenzenes promoted by sulfur oxo salts. / P. Volodymyr та ін. ChemRxiv. 2026. DOI: 10.26434/chemrxiv.15005066/v1 (дата звернення: 11.09.2026).
A simple, cost-effective, scalable, and environmentally friendly method for the synthesis of benzimidazoles from corresponding ortho-dinitrobenzenes or ortho-nitroanilines, starting from the simplest carboxylic acids and promoted by Na2S2O4, has been developed. The reaction scope looks promising; substrates bearing various substituents (electron-withdrawing, electron-donating, and halogenated), including free OH, carboxylic, ester, and acetyl groups, were introduced. The products were formed in high yields (52-88%) and purified without tedious chromatographic methods.
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