Complexation of Calix[4]arene bis-Hydroxymethylenediphosphonic Acid with Amino acids. Binding Constants Determination by RP HPLC Method
Тип публікації :
Стаття
Дата випуску :
2015
Автор(и) :
Kalchenko, Vitaly Ivanovich
Kalchenko, Olga
Cherenok, Sergiy
Мова основного тексту :
Англійська
eKNUTSHIR URL :
Том :
3
Випуск :
2
ISSN :
2312-3222
Початкова сторінка :
93
Кінцева сторінка :
100
Цитування :
[APA 7] Kalchenko, V. I., Kalchenko, O., & Cherenok, S. (2015). Complexation of Calix[4]arene bis-Hydroxymethylenediphosphonic Acid with Amino acids. Binding Constants Determination by RP HPLC Method. French-Ukrainian Journal of Chemistry, 3(2), 93–100. https://doi.org/10.17721/fujcV3I2P93-100
[ДСТУ] Kalchenko V. I., Kalchenko O., Cherenok S. Complexation of Calix[4]arene bis-Hydroxymethylenediphosphonic Acid with Amino acids. Binding Constants Determination by RP HPLC Method. French-Ukrainian Journal of Chemistry. 2015. Vol. 3, no. 2. P. 93—100. DOI: 10.17721/fujcV3I2P93-100 (date of access: 25.07.2026).
Host-Guest complexation of calixarene-bis-hydroxymethylenediphosphonic acid with 17 amino acids in water solution had been studied by the RP HPLC and molecular modelling methods. It had been shown the binding constants of the complexes are depended on the nature of the amino acid residue, log P and pKa of the acids. The complexation is mainly determined by the electrostatic interactions between the positively charged nitrogen atom of the amino acid and the negatively charged oxygen atom of phosphonic acid residue of the calixarene, the Host-Guest p-p, СН-p and solvophobic interactions.
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