Matviiuk, TetianaTetianaMatviiukGorichko, MarianMarianGorichkoLherbet, ChristianChristianLherbetRodriguez, FredericFredericRodriguezBaltas, MichelMichelBaltasRosalia Pasca, MariaMariaRosalia PascaVoitenko, ZoiaZoiaVoitenko2026-06-262026-06-262013Matviiuk, T., Gorichko, M., Lherbet, C., Rodriguez, F., Baltas, M., Rosalia Pasca, M., Voitenko, Z. (2013). Synthesis of Potential Inhibitors of InhA with Pyrrolidine-2,5-dione Core Fragment and Evaluation of their Biological Activity. French-Ukrainian Journal of Chemistry, 1(1), 15–22.https://ir.library.knu.ua/handle/15071834/25615We report here the discovery, synthesis and screening results of the series of 3-bulky substituted pyrrolidine-2,5-dione derivatives as a novel class of potential inhibitors on InhA, a key enzyme involved in the fatty acid biosynthesis pathway (type II) of M. tuberculosis as well as inhibitors of Mycobacterium tuberculosis H37Rv.ensubstituted pyrrolidine-25-dioneinhibitors of InhAsynthesisСтаття