Menendez, ChristopheChristopheMenendezMori, GiorgiaGiorgiaMoriMaillot, MathildeMathildeMaillotFabing, IsabelleIsabelleFabingCarayon, ChantalChantalCarayonSilvia Orena, BéatriceBéatriceSilvia OrenaRosalia Pasca, MariaMariaRosalia PascaVoitenko, ZoiaZoiaVoitenkoLherbet, ChristianChristianLherbetBaltas, MichelMichelBaltas2026-06-262026-06-262015Menendez, C., Mori, G., Maillot, M., Fabing, I., Carayon, C., Silvia Orena, B., Rosalia Pasca, M., Voitenko, Z., Lherbet, C., Baltas, M. (2015). Synthesis and evaluation of β-hydroxytriazoles and related compounds as antitubercular agents. French-Ukrainian Journal of Chemistry, 3(1), 82–96. https://doi.org/10.17721/fujcV3I1P82-9610.17721/fujcV3I1P82-96https://ir.library.knu.ua/handle/15071834/25586A new series of β-hydroxytriazoles were synthesized and evaluated as Mycobacterium tuberculosis inhibitors. Our strategy implied the synthesis of alkyne precursors through a Barbier reaction between benzaldehydes and propargyl bromide followed by click chemistry to afford substituted β-hydroxyl benzyltriazoles. These compounds are also key intermediates either for oxidation reactions leading to α,β-diketotriazoles or for elimination reactions affording styryl triazoles. Evaluation of all new compounds for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv resulted in compounds with MIC up to 7 μM.enMycobacterium tuberculosisβ-hydroxytriazoleαβ-diketotriazoleoxidationIBXinhibitionСтаття