Fedosenko, GannaGannaFedosenkoYegorova, AllaAllaYegorovaScrypynets, YuliaYuliaScrypynetsLeonenko, InnaInnaLeonenkoVitukova, EkaterinaEkaterinaVitukova2026-06-262026-06-262018Fedosenko, G., Yegorova, A., Scrypynets, Y., Leonenko, I., Vitukova, E. (2018). Determination of Fenspiride Hydrochloride Residues on Pharmaceutical Manufacturing Equipment Surfaces by HPLC Method. French-Ukrainian Journal of Chemistry, 6(1), 7–15. https://doi.org/10.17721/fujcV6I1P7-1510.17721/fujcV6I1P7-15https://ir.library.knu.ua/handle/15071834/25504The cleaning procedure must be validated, so special attention must be devoted to the methods used for determination of trace amounts of drugs. A rapid, sensitive, and specific reverse phase high-performance liquid chromatographic (HPLC) method was developed for the quantitative determination of fenspiride hydrochloride residues on pharmaceutical manufacturing equipment surfaces. The calibration curve was linear over a concentration range from 1.0 to 100.0 μg/ml with a correlation coefficient of 0.99994. The detection limit and quantitation limit were 0.41 μg/ml and 1.25 μg/ml, respectively. The developed method was validated with respect to specificity, linearity, limit of detection, accuracy and precision.encleaning validationfenspiride hydrochlorideresiduesswab analysisHPLCСтаття