Near-infrared light at 808 nm reduces B-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer`s disease in vitro model

Near-infrared light at 808 nm reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons in Alzheimer's disease in vitro model [Електронне видання] / Golovynska I. et.al. Poster number: 12826-19. Електронні текстові дані (1 файл: 0,15 Мбайт). 2024. 1 с. Назва з екрана.

Photobiomodulation (PBM) with 808 nm laser light was applied to microglia cells treated with β-amyloids (Aβ). The light irradiation resulted in a metabolic shift from glycolysis to mitochondrial activity in pro-inflammatory microglia affected by Aβ, leading to an increase in anti-inflammatory microglia. This process was shown to be accompanied by a decrease in pro-inflammatory cytokines and an activation of phagocytosis. PBM also caused a decrease in the Aβ-induced activity of glucose-6-phosphate dehydrogenase, an enzyme regulating the rate of the pentose phosphate pathway, which activates nicotinamide adenine dinucleotide phosphate oxidases to further produce ROS. During co-cultivation of neurons and microglia, irradiation with 808 nm light was found to prevent the death of neurons, which was caused by ROS produced by Aβ-altered microglia. The obtained data clarify mechanisms of PBM protection against neurodegeneration and support the use of NIR light in the treatment of Alzheimer's disease.