Investigation of structural features of SARS-CoV-2 S-protein interaction with lipid membranes by small-angle neutron scattering

Тип публікації :
Стаття
Дата випуску :
2021
Автор(и) :
Соловйов, Д. В.
Іваньков, О. І.
Булавін, Л. А.
Дорошенко, Ірина Ю.
Онук, М. М.
Мова основного тексту :
Англійська
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DOI :
Журнал :
Випуск :
2
ISSN :
1812-5409
Початкова сторінка :
127
Кінцева сторінка :
130
Цитування :
[APA 7] Соловйов, Д. В., Іваньков, О. І., Булавін, Л. А., Дорошенко, І. Ю., & Онук, М. М. (2021). Investigation of structural features of SARS-CoV-2 S-protein interaction with lipid membranes by small-angle neutron scattering. Bulletin of Taras Shevchenko National University of Kyiv. Physics and Mathematics, (2), 127–130. https://doi.org/10.17721/1812-5409.2021/2.17
[ДСТУ] Investigation of structural features of SARS-CoV-2 S-protein interaction with lipid membranes by small-angle neutron scattering / Д. В. Соловйов et al. Bulletin of Taras Shevchenko National University of Kyiv. Physics and Mathematics. 2021. no. 2. P. 127—130. DOI: 10.17721/1812-5409.2021/2.17 (date of access: 18.07.2026).
The effect of SARS-CoV-2 coronavirus S-protein on the structural parameters of the model lipid membrane on dimyristoylphosphatidylcholine (DMPC) systems with cholesterol and melatonin impurities was studied by the method of small angle neutron scattering. It is shown that an increase in the concentration of melatonin in the lipid membrane leads to a decrease in the thickness of the lipid bilayer, and an increase in the concentration of cholesterol leads to an increase in it. It has been suggested that increasing the concentration of melatonin in the membrane prevents the interaction of coronaviral S-protein with the lipid membrane of the cell. In the presence of cholesterol impurities in the system, the interaction of the lipid membrane with the active part of the S-protein occurs depending on the phase state of the lipid. Thus, when the lipid is in the gel phase (at 10 ° C), the active part of the S-protein does not change the structural parameters of the lipid bilayer, i.e. the interaction between the lipid membrane and the active part of the S-protein does not occur. At 37 ° C, when the lipid is in the liquid crystalline phase, the addition of RBD SARS-CoV-2 in the system DMPC / 30% Cholesterol / D2O leads to a decrease in membrane thickness, indicating the interaction of S-protein with the membrane.
Pages of the article in the issue: 127 - 130
Language of the article: Ukrainian
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